Balkovec, James M. : rechercher sur Z-Library

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1

The First Stereoselective Total Synthesis of Quinine

Niu, Deqiang, Fujimoto, A., Koft, Emil R., Balkovec, James M., Tata, James R., Dake, Gregory R., Stork, Gilbert

Journal:

Journal of the American Chemical Society

Année:

2001

Langue:

english

Fichier:

PDF, 120 KB

english, 2001

2

Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin

Apgar, James M., Wilkening, Robert R., Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming Jo, Liberator,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2015

3

Synthesis and structure-activity relationships of novel 3′-Hty-substituted pneumocandins

Regina M Black, James M Balkovec, Karl M Nollstadt, Sarah Dreikorn, Kenneth F Bartizal, George K Abruzzo

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 361 KB

english, 1997

4

Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase

Heasley, Brian H., Pacofsky, Gregory J., Mamai, Ahmed, Liu, Hao, Nelson, Kingsley, Coti, Ghjuvanni, Peel, Michael R., Balkovec, James M., Greenlee, Mark L., Liberator, Paul, Meng, Dongfang, Parker, Da

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 813 KB

english, 2012

5

Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives

Bouffard, F. Aileen, Zambias, Robert A., Dropinski, James F., Balkovec, James M., Hammond, Milton L., Abruzzo, George K., Bartizal, Kenneth F., Marrinan, Jean A., Kurtz, Myra B.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 520 KB

english, 1994

6

A total synthesis of plumericin, allamcin and allamandin. Part 2. A biomimetic strategy

Trost, Barry M., Balkovec, James M., Mao, Michael K. T.

Journal:

Journal of the American Chemical Society

Année:

1986

Langue:

english

Fichier:

PDF, 1.40 MB

english, 1986

7

[Pharmacochemistry Library] Proceedings XIVth International Symposium on Medicinal Chemistry Volume 28 || The fungal cell wall as a drug discovery target: SAR of novel echinocandin analogs

Balkovec, James M.

Année:

1997

Langue:

english

Fichier:

PDF, 712 KB

english, 1997

8

The First Stereoselective Total Synthesis of Quinine.

Gilbert Stork, Deqiang Niu, A. Fujimoto, Emil R. Koft, James M. Balkovec, James R. Tata, Gregory R. Dake

Journal:

Année:

2001

Fichier:

PDF, 23 KB

2001

9

4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

Yuping Zhu, Steven H. Olson, Anne Hermanowski-Vosatka, Steven Mundt, Kashmira Shah, Marty Springer, Rolf Thieringer, Samuel Wright, Jianying Xiao, Hratch Zokian, James M. Balkovec

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 294 KB

english, 2008

10

Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B0 derivatives

Robert A. Zambias, Catherine James, Milton L. Hammond, George K. Abruzzo, Kenneth F. Bartizal, Karl H. Nollstadt, Cameron Douglas, Jean Marrinan, James M. Balkovec

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 326 KB

english, 1995

11

Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat

Amjad Ali, James M. Balkovec, Mark Greenlee, Milton L. Hammond, Greg Rouen, Gayle Taylor, Monica Einstein, Lan Ge, Georgianna Harris, Terri M. Kelly, Paul Mazur, Shilpa Pandit, Joseph Santoro, Ayesha

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 263 KB

english, 2008

12

Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Christopher F. Thompson, Nazia Quraishi, Amjad Ali, James R. Tata, Milton L. Hammond, James M. Balkovec, Monica Einstein, Lan Ge, Georgianna Harris, Theresa M. Kelly, Paul Mazur, Shilpa Pandit, Joseph

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 127 KB

english, 2005

13

Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity

Cameron J. Smith, Amjad Ali, James M. Balkovec, Donald W. Graham, Milton L. Hammond, Gool F. Patel, Gregory P. Rouen, Scott K. Smith, James R. Tata, Monica Einstein, Lan Ge, Georgianna S. Harris, Ther

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 234 KB

english, 2005

14

Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments

Christopher F. Thompson, Nazia Quraishi, Amjad Ali, Ralph T. Mosley, James R. Tata, Milton L. Hammond, James M. Balkovec, Monica Einstein, Lan Ge, Georgianna Harris, Terri M. Kelly, Paul Mazur, Shilpa

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 331 KB

english, 2007

15

Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome

Milana Maletic, Aaron Leeman, Michael Szymonifka, Steven S. Mundt, Hratch J. Zokian, Kashmira Shah, Jasminka Dragovic, Kathy Lyons, Rolf Thieringer, Anne H. Vosatka, James Balkovec, Sherman T. Waddell

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 629 KB

english, 2011

16

Substituted phenyl triazoles as selective inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Wanying Sun, Milana Maletic, Steven S. Mundt, Kashmira Shah, Hratch Zokian, Kathy Lyons, Sherman T. Waddell, James Balkovec

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 676 KB

english, 2011

17

Reduction studies of antifungal echinocandin lipopeptides. One step conversion of echinocandin B to echinocandin C.

James M. Balkovec, Regina M. Black

Journal:

Tetrahedron Letters

Année:

1992

Langue:

english

Fichier:

PDF, 306 KB

english, 1992

18

Synthesis of 4-methylene-1-cyclopentenes

Barry M. Trost, James M. Balkovec, Steven R. Angle

Journal:

Tetrahedron Letters

Année:

1986

Langue:

english

Fichier:

PDF, 184 KB

english, 1986

19

The total synthesis of allamandin

Barry M. Trost, James M. Balkovec

Journal:

Tetrahedron Letters

Année:

1985

Langue:

english

Fichier:

PDF, 173 KB

english, 1985

20

Lipopeptide antifungal agents: Amine conjugates of the semi-synthetic pneumocandins L-731,373 and L-733,560

Robert A. Zambias, Catherine James, George K. Abruzzo, Kenneth F. Bartizal, Richard Hajdu, Randy Thompson, Karl H. Nollstadt, Jean Marrinan, James M. Balkovec

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 353 KB

english, 1997

21

Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast

Bruno Tse, James M. Balkovec, Charles M. Blazey, Ming-Jo Hsu, Jennifer Nielsen, Dennis Schmatz

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 213 KB

english, 1998

22

Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase

Mark L. Greenlee, Joanne B. Laub, James M. Balkovec, Milton L. Hammond, Gail G. Hammond, David L. Pompliano, Jeffrey H. Epstein-Toney

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 408 KB

english, 1999

23

Pneumocandin antifungal lipopeptides. The phenolic hydroxyl is required for 1,3-β-glucan synthesis inhibition.

James M. Balkovec, Regina M. Black, George K. Abruzzo, Ken Bartizal, Sarah Dreikorn, Nollstadt Karl

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1993

Langue:

english

Fichier:

PDF, 306 KB

english, 1993

24

Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives

Gail G. Hammond, Joann L. Huber, Mark L. Greenlee, Joanne B. Laub, Katherine Young, Lynn L. Silver, James M. Balkovec, KellyAnn D. Pryor, Joseph K. Wu, Barbara Leiting, David L. Pompliano, Jeffrey H.

Journal:

FEMS Microbiology Letters

Année:

1999

Langue:

english

Fichier:

PDF, 316 KB

english, 1999

25

Synthesis of oxaspiropiperidines as a strategy for lowering log D

Timothy Cernak, Kevin Dykstra, Dorothy Levorse, Andreas Verras, James Balkovec, Ravi Nargund, Robert DeVita

Journal:

Tetrahedron Letters

Année:

2011

Langue:

english

Fichier:

PDF, 612 KB

english, 2011

26

Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives

Gail G. Hammond, Joann L. Huber, Mark L. Greenlee, Joanne B. Laub, Katherine Young, Lynn L. Silver, James M. Balkovec, KellyAnn D. Pryor, Joseph K. Wu, Barbara Leiting, David L. Pompliano, Jeffrey H.

Journal:

FEMS Microbiology Letters

Année:

1999

Langue:

english

Fichier:

PDF, 319 KB

english, 1999

27

[Annual Reports in Medicinal Chemistry] Volume 33 || Non-Azole Antifungal Agents

Balkovec, James M.

Année:

1998

Langue:

english

Fichier:

PDF, 753 KB

english, 1998

28

Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP)

Balkovec, James M., Black, Regina M., Hammond, Milton L., Heck, James V., Zambias, Robert A., Abruzzo, George, Bartizal, Ken, Kropp, Helmut, Trainor, Charlotte

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 718 KB

english, 1992

29

A biomimetic approach to plumericin

Trost, Barry M., Balkovec, James M., Mao, Michael K. T.

Journal:

Journal of the American Chemical Society

Année:

1983

Langue:

english

Fichier:

PDF, 397 KB

english, 1983

30

Determination of the Absolute Stereochemistry of (−)-Galbonolide A

Tse, Bruno, Blazey, Charles M., Tu, Ben, Balkovec, James

Journal:

Journal of Organic Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 186 KB

english, 1997

31

Novel N- Arylpyrazolo[3,2- c ]-Based Ligands for the Glucocorticoid Receptor: Receptor Binding and in Vivo Activity

Ali, Amjad, Thompson, Christopher F., Balkovec, James M., Graham, Donald W., Hammond, Milton L., Quraishi, Nazia, Tata, James R., Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Terri M., Mazur,

Journal:

Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 274 KB

english, 2004

32

The First Stereoselective Total Synthesis of Quinine [ J. Am. Chem. Soc. 2001 , 123 (14), 3239−3242].

Stork, Gilbert, Niu, Deqiang, Fujimoto, Roger A., Koft, Emil R., Balkovec, James M., Tata, James R., Dake, Gregory R.

Journal:

Journal of the American Chemical Society

Année:

2001

Langue:

english

Fichier:

PDF, 38 KB

english, 2001

33

On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols

Trost, Barry M., Belletire, John L., Godleski, Stephen, McDougal, Patrick G., Balkovec, James M., Baldwin, John J., Christy, Marcia E., Ponticello, Gerald S., Varga, Sandor L., Springer, James P.

Journal:

Journal of Organic Chemistry

Année:

1986

Langue:

english

Fichier:

PDF, 593 KB

english, 1986

34

A total synthesis of plumericin, allamcin, and allamandin. Part 1. Basic strategy

Trost, Barry M., Mao, Michael K. T., Balkovec, James M., Buhlmayer, Peter.

Journal:

Journal of the American Chemical Society

Année:

1986

Langue:

english

Fichier:

PDF, 1.19 MB

english, 1986

35

Section Review: Anti-infectives: Lipopeptide antifungal agents

Balkovec, James M

Journal:

Expert Opinion on Investigational Drugs

Année:

1994

Langue:

english

Fichier:

PDF, 1.88 MB

english, 1994

36

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin

Ong, Voon, Hough, Grayson, Schlosser, Michael, Bartizal, Ken, Balkovec, James M., James, Kenneth D., Krishnan, B. Radha

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2016

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2016

37

Basic carbapenem analogs: Synthesis and in vitro activity of 1.BETA.-methyl-2-(pyridylmethylthio)-carbapenems.

BALKOVEC, JAMES M., SZYMONIFKA, MICHAEL J., HECK, JAMES V., RATCLIFFE, RONALD W.

Journal:

The Journal of Antibiotics

Année:

1991

Langue:

english

Fichier:

PDF, 326 KB

english, 1991

38

MK-5204: an orally active Î²-1,3-glucan synthesis inhibitor

Apgar, James M., Wilkening, Robert R., Parker, Dann L., Meng, Dongfang, Wildonger, Kenneth J., Sperbeck, Donald, Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, A

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2020

Fichier:

PDF, 451 KB

2020

39

Efficacy of MK-991 (L-743,872), a Semisynthetic Pneumocandin, in Murine Models ofPneumocystis carinii

Powles, Mary Ann, Liberator, Paul, Anderson, Jennifer, Karkhanis, Yashwant, Dropinski, James F., Bouffard, F. Aileen, Balkovec, James M., Fujioka, Hisashi, Aikawa, Masamichi, McFadden, Diane, Schmatz,

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1998

Fichier:

PDF, 1.06 MB

1998

40

Ibrexafungerp: an orally active Î²-1,3-glucan synthesis inhibitor

Apgar, James M., Wilkening, Robert R., Parker, Dann L., Meng, Dongfang, Wildonger, Kenneth J., Sperbeck, Donald, Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, A

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2020

Fichier:

PDF, 462 KB

2020